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The Effect of High-Dose Steroids on MRI Gadolinium Enhancement in Acute Demyelinating Lesions Neurol 41:1349-1354, Burnham,J.A.,et al, 1991 See this aricle in Pubmed Article Abstract Gadolinium(Gd)enhancement of brain lesions by MRI is a marker of active blood-brain barrier damage secondary to an inflammatory process.We studied the effects of high-dose(1,000 mg/d)intravenous(IV)methylprednisolone(Mp) for 4 to 8 days on Gd-enhancing lesions in seven patients with acute demyelinating diseases compared pretreatment brain MRIs with studies obtained 1 to 4 days after treatment.Five patients had complete suppression,and two had significant suppression of Gd enhancement following treatment.In addition,six of seven patients had Gd-enhancing lesions that explained their clinical signs;in five of six of these patients,suppression of the Gd-enhanced lesions temporally correlated with clinical improvement.Thus,short courses of high-dose IV Mp suppress Gd enhancement in acute demyelinating lesions,and this correlates with clinical improvement.

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